Could you ask Dr. Voliocelli to discuss the difference between addiction and dependence?
These terms often used interchangeably, but I understand dependence involves replacing an endogenous substance with an external one, while addiction refers more to a set of behaviors that may or may not include dependence.
For example, when someone takes opioids, their natural (endogenous) opioid system can go offline, leading to physical dependence and withdrawal when the external source is stopped — that’s classical dependence, which may or may not involve addictive behaviors.
Is that distinction accurate, and does Naltrexone work on addiction, dependence, or both? I realize I’m simplifying a complex topic, but I still think it’s one worth exploring and clarifying and more people understood. Thanks!
Hi there, I’m a therapist who works with AUD, and my primary concern is getting prescribers (PCPs and/or psych providers) on board with the Sinclair Method. It is outside of my scope to recommend that a patient take a medication (or take it in a particular way), so the only way I can recommend the Sinclair Method is with a prescriber’s approval. Does Dr. Volpicelli have any resources (handouts, websites, etc) that I can use to demonstrate the safety/efficacy of this treatment to other medical professionals? Thank you Katie!! Bought the book and am loving it so far.
Naltrexone doesn't seem to "work" for me the way it's supposed to. It doesn't kill my buzz (if anything, it makes me feel drunker), but what it does seem to do is lower my tolerance so I feel the need to drink less. Is that something you've seen in others? And if so, have those people been able to reach pharmacological extinction?
Does it work for stimulants?
Also my question
Could you ask Dr. Voliocelli to discuss the difference between addiction and dependence?
These terms often used interchangeably, but I understand dependence involves replacing an endogenous substance with an external one, while addiction refers more to a set of behaviors that may or may not include dependence.
For example, when someone takes opioids, their natural (endogenous) opioid system can go offline, leading to physical dependence and withdrawal when the external source is stopped — that’s classical dependence, which may or may not involve addictive behaviors.
Is that distinction accurate, and does Naltrexone work on addiction, dependence, or both? I realize I’m simplifying a complex topic, but I still think it’s one worth exploring and clarifying and more people understood. Thanks!
Hi there, I’m a therapist who works with AUD, and my primary concern is getting prescribers (PCPs and/or psych providers) on board with the Sinclair Method. It is outside of my scope to recommend that a patient take a medication (or take it in a particular way), so the only way I can recommend the Sinclair Method is with a prescriber’s approval. Does Dr. Volpicelli have any resources (handouts, websites, etc) that I can use to demonstrate the safety/efficacy of this treatment to other medical professionals? Thank you Katie!! Bought the book and am loving it so far.
I never saw a replay for this come up, can I still watch it?
Naltrexone doesn't seem to "work" for me the way it's supposed to. It doesn't kill my buzz (if anything, it makes me feel drunker), but what it does seem to do is lower my tolerance so I feel the need to drink less. Is that something you've seen in others? And if so, have those people been able to reach pharmacological extinction?
Some primos have reported that naltrexone itself has unpleasant enough side effects that they have a hard time taking it, even at reduced doses.
Does Dr. V have any information or insight into low-dose naltrexone regimens and how they differ from addiction-extinction dosing and treatment?
Maybe of interest:
Reductions in World Health Organization Risk Drinking Levels as a Primary Efficacy End Point for Alcohol Clinical Trials
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2838990
See you there!!
I’ll be there!
+1 to this question.